SFRP5

Across TCGA cell cohorts, SFRP5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SFRP5-associated genes across cancer lineages are DBX1, KIR3DL1, and GPR139. Each is linked with SFRP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFRP5-to-partner and partner-to-SFRP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX1 grouped by SFRP5-low versus SFRP5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP5→partner) and Y-score (partner→SFRP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DBX1 →	+0.649	+4.315	<.001	.006	3	1
CNS	KIR3DL1 →	+0.024	+4.754	<.001	.005	3	1
CNS	GPR139 →	+0.027	+5.357	<.001	.001	3	1
CNS	HTN3 →	+1.082	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DBX1 by SFRP5 expression — CNS

Explore this box plot interactively →