SFRP4

Across TCGA pan-cancer cohorts, SFRP4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SFRP4 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SFRP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SFRP4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where SFRP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.265	0.878	.001	29	view →
PDAC	DFS	Median	All	0.908	0.685	.002	27	view →
HNSC	OS	Tertile	III,IV	0.964	0.779	.006	19	view →
CCRCC	DFS	Quartile	III,IV	0.157	0.743	.011	17	view →
COAD	DFS	Median	III,IV	0.829	1.000	.027	6	view →
LUAD	OS	Tertile	All	0.797	0.894	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SFRP4–LSCC (DFS)

Open the LSCC breakdown →