SFRP4

Across TCGA cell cohorts, SFRP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,969 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SFRP4-associated GO terms across cancer lineages are Positive regulation of Ras protein signal transduction, Endosome organization, and Glycoprotein catabolic process. Each is linked with SFRP4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SFRP4-to-partner and partner-to-SFRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of Ras protein signal transduction grouped by SFRP4-low versus SFRP4-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP4→partner) and Y-score (partner→SFRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of Ras protein signal transduction →	+0.156	+0.104	<.001	.003	3	5
KIDNEY	Endosome organization →	+0.081	+2.352	<.001	<.001	3	5
BONE	Glycoprotein catabolic process →	+0.141	+0.926	<.001	.006	3	5
BONE	Endoplasmic reticulum to cytosol transport →	+0.119	+0.947	<.001	.005	3	5
BONE	Retrograde protein transport, ER to cytosol →	+0.119	+0.947	<.001	.005	3	5
BONE	Protein exit from endoplasmic reticulum →	+0.181	+1.380	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,969 associations by consensus.

Positive regulation of Ras protein signal transduction by SFRP4 expression — BLOOD_Myeloma

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