SFRP2

Across TCGA pan-cancer cohorts, SFRP2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SFRP2 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SFRP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SFRP2 expression acts as an unfavorable survival marker.

COAD, PDAC, and LUAD are the cancer types where SFRP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.878	1.000	.017	18	view →
PDAC	DFS	Quartile	III,IV	0.160	0.467	.017	9	view →
LUAD	OS	Median	II,III,IV	0.509	0.745	.029	5	view →
LSCC	DFS	Quartile	All	0.291	0.913	.006	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SFRP2–COAD (DFS)

Open the COAD breakdown →