SFR1

Across TCGA pan-cancer cohorts, SFR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SFR1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SFR1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SFR1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, OV, and LUAD are the cancer types where SFR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.923	0.599	.003	18	view →
OV	DFS	Quartile	All	0.446	0.819	.039	8	view →
LUAD	DFS	Median	II,III,IV	0.913	0.667	.004	7	view →
PDAC	OS	Tertile	III,IV	0.464	0.936	.024	7	view →
CCRCC	DFS	Median	III,IV	0.533	1.000	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SFR1–LSCC (OS)

Open the LSCC breakdown →