SFPQ

Across TCGA pan-cancer cohorts, SFPQ mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SFPQ data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SFPQ mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SFPQ expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where SFPQ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.688	0.883	.008	28	view →
COAD	DFS	Median	All	1.000	0.893	.030	18	view →
LUAD	OS	Tertile	All	0.964	0.780	.007	14	view →
GBM	OS	Median	All	0.494	0.283	.006	9	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SFPQ–HNSC (DFS)

Open the HNSC breakdown →