SFPQ

Across TCGA patient cohorts, SFPQ mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFPQ-associated genes across cancer lineages are ATM, ASNS, and c-Met_pY1235. Each is linked with SFPQ in more than 2 cancer types. Because this analysis shows association rather than direction, both SFPQ-to-partner and partner-to-SFPQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SFPQ-low versus SFPQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFPQ→partner) and Y-score (partner→SFPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.452	-1.906	.013	.016	3	3
UCEC	ASNS →	+0.469	+2.807	.001	.003	3	2
UCEC	c-Met_pY1235 →	+0.063	+2.331	.034	.019	3	2
UCEC	A-Raf_pS299 →	-0.098	-2.415	.042	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-2.584	.009	.010	3	1
UCEC	mTOR_pS2448 →	-0.130	-2.446	.030	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ATM by SFPQ expression — UCEC

Explore this box plot interactively →