SFPQ

Across TCGA cell cohorts, SFPQ mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SFPQ-associated genes across cancer lineages are PTX4, MAGEB4, and GAGE12D. Each is linked with SFPQ in more than 1 cancer types. Because this analysis shows association rather than direction, both SFPQ-to-partner and partner-to-SFPQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTX4 grouped by SFPQ-low versus SFPQ-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFPQ→partner) and Y-score (partner→SFPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTX4 →	+0.067	+3.321	.002	.007	3	2
LARGE_INTESTINE	MAGEB4 →	+0.019	+5.000	<.001	<.001	3	2
SKIN	GAGE12D →	+4.295	+4.977	<.001	.007	3	1
SKIN	GAGE12C →	+4.062	+5.415	<.001	.004	3	1
LUNG_SCLC	F13B →	+0.109	+3.665	<.001	.004	3	1
LUNG_SCLC	OR10K1 →	+0.286	+4.029	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PTX4 by SFPQ expression — OVARY

Explore this box plot interactively →