Across TCGA patient cohorts, SFMBT2 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFMBT2-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and ACVRL1. Each is linked with SFMBT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SFMBT2-to-partner and partner-to-SFMBT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFMBT2→partner) and Y-score (partner→SFMBT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.412	+3.000	.006	.035	3	4
UCEC	Cyclin-B1 →	+0.623	+1.784	<.001	<.001	3	3
UCEC	ACVRL1 →	-0.095	-1.893	.014	.014	3	3
UCEC	Shc_pY317 →	-0.144	-1.584	<.001	.001	3	3
COAD	ASNS →	+0.378	+2.087	.001	.004	3	3
STAD	GAPDH →	+0.411	+2.584	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

SFMBT2 survival (RNA) · tumor vs normal (RNA) · all SFMBT2 data types