SFMBT1

Across TCGA patient cohorts, SFMBT1 mutation is significantly associated with the RNA expression of many other genes, with 3,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFMBT1-associated genes across cancer lineages are SKA1, CHAF1B, and LINC02262. Each is linked with SFMBT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SFMBT1-to-partner and partner-to-SFMBT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by SFMBT1-low versus SFMBT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFMBT1→partner) and Y-score (partner→SFMBT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.731	+2.332	<.001	<.001	3	3
UCEC	CHAF1B →	+0.538	+2.016	<.001	.001	3	3
HNSC	LINC02262 →	+0.106	+4.748	.001	.003	3	3
UCEC	PIMREG →	+0.599	+1.480	.005	.008	3	3
UCEC	YARS1 →	+0.584	+2.346	<.001	<.001	3	3
SKCM	RN7SKP25 →	+0.048	+2.943	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,148 associations by consensus.

SKA1 by SFMBT1 expression — UCEC

Explore this box plot interactively →