Across TCGA pan-cancer cohorts, SFI1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SFI1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SFI1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SFI1 expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

LUAD, GBM, and UCEC are the cancer types where SFI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.790	1.000	.006	12	view →
GBM	OS	Tertile	All	0.622	0.266	.024	6	view →
UCEC	DFS	Tertile	All	1.000	0.873	.040	2	view →
CCRCC	DFS	Median	All	1.000	0.545	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SFI1 tumor-vs-normal RNA expression · all SFI1 data types