Across TCGA patient cohorts, SFI1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFI1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Cyclin-E1. Each is linked with SFI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SFI1-to-partner and partner-to-SFI1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFI1→partner) and Y-score (partner→SFI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.444	-2.794	.001	.002	3	4
UCEC	Caspase-7-cleavedD198 →	+0.398	+1.867	.026	.004	3	3
BLCA	Cyclin-E1 →	+0.392	+3.169	.020	.018	3	2
UCEC	eEF2 →	+0.214	+1.415	.047	.043	3	2
UCEC	MEK1 →	+0.311	+2.321	.004	.005	3	2
UCEC	MSH6 →	-0.318	-2.321	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

SFI1 survival (RNA) · tumor vs normal (RNA) · all SFI1 data types