Across TCGA cell cohorts, SFI1 mutation is significantly associated with the RNA expression of many other genes, with 330 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SFI1-associated genes across cancer lineages are MYO5B, KRTAP10-12, and LORICRIN. Each is linked with SFI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFI1-to-partner and partner-to-SFI1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFI1→partner) and Y-score (partner→SFI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYO5B →	+1.040	+3.502	.003	.001	3	2
SOFT_TISSUE	KRTAP10-12 →	+0.045	+5.369	<.001	.004	3	1
SOFT_TISSUE	LORICRIN →	+0.021	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR10G4 →	+0.048	+4.930	<.001	.008	3	1
KIDNEY	C11orf53 →	+0.033	+5.000	<.001	.005	3	1
KIDNEY	GPR33 →	+0.023	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 330 associations by consensus.

Exploration

SFI1 survival (RNA) · tumor vs normal (RNA) · all SFI1 data types