SF3B6

Across TCGA pan-cancer cohorts, SF3B6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SF3B6 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SF3B6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SF3B6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

HNSC, LSCC, and UCEC are the cancer types where SF3B6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.929	0.991	.011	13	view →
LSCC	OS	Quartile	II,III,IV	0.931	0.479	.006	10	view →
UCEC	DFS	Median	All	1.000	0.936	.023	4	view →
LUAD	OS	Quartile	III,IV	0.993	0.427	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SF3B6–HNSC (OS)

Open the HNSC breakdown →