SF3B6

Across TCGA patient cohorts, SF3B6 mutation is significantly associated with the RNA expression of many other genes, with 165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3B6-associated genes across cancer lineages are RNA5SP409, MTHFD2P7, and RPL14P6. Each is linked with SF3B6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B6-to-partner and partner-to-SF3B6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP409 grouped by SF3B6-low versus SF3B6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B6→partner) and Y-score (partner→SF3B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP409 →	+0.345	+7.741	<.001	.009	3	1
UCEC	MTHFD2P7 →	+0.385	+3.002	<.001	.004	3	1
UCEC	RPL14P6 →	+0.276	+2.432	<.001	.009	3	1
UCEC	RNA5SP260 →	+0.756	+3.173	<.001	.002	3	1
UCEC	RNA5SP161 →	+1.170	+2.528	<.001	.006	3	1
UCEC	RN7SKP230 →	+0.512	+2.632	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 165 associations by consensus.

RNA5SP409 by SF3B6 expression — COAD

Explore this box plot interactively →