SF3B6

Across TCGA patient cohorts, SF3B6 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3B6-associated genes across cancer lineages are p90 RSK, Annexin-1, and Shc_pY317. Each is linked with SF3B6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B6-to-partner and partner-to-SF3B6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by SF3B6-low versus SF3B6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B6→partner) and Y-score (partner→SF3B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.229	+3.009	.029	.019	3	1
UCEC	Annexin-1 →	+0.831	+3.019	.004	.019	3	1
UCEC	Shc_pY317 →	-0.250	-3.169	.002	.020	3	1
UCEC	CDK1 →	+0.270	+3.169	.001	.020	3	1
UCEC	P-Cadherin →	-0.211	-3.156	.007	.020	2	1
UCEC	Caspase-8 →	-0.332	-3.169	.016	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

p90 RSK by SF3B6 expression — UCEC

Explore this box plot interactively →