SF3B6

Across TCGA cell cohorts, SF3B6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,576 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SF3B6-associated GO terms across cancer lineages are Protein linear polyubiquitination, Positive regulation of lipid metabolic process, and DAMP biosynthetic process. Each is linked with SF3B6 in more than 12 cancer types. Because this analysis shows association rather than direction, both SF3B6-to-partner and partner-to-SF3B6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein linear polyubiquitination grouped by SF3B6-low versus SF3B6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B6→partner) and Y-score (partner→SF3B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein linear polyubiquitination →	-0.128	-0.884	.004	<.001	3	13
KIDNEY	Positive regulation of lipid metabolic process →	-0.051	-0.414	.002	<.001	3	13
URINARY_TRACT	DAMP biosynthetic process →	+0.152	+0.567	<.001	.003	3	12
URINARY_TRACT	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.152	+0.567	<.001	.003	3	12
PANCREAS	Pentose-phosphate shunt, non-oxidative branch →	+0.136	+0.708	<.001	<.001	3	11
KIDNEY	Regulation of protein localization to endoplasmic reticulum →	-0.142	-0.543	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,576 associations by consensus.

Protein linear polyubiquitination by SF3B6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →