Across TCGA pan-cancer cohorts, SF3B3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SF3B3 data layer compared with 21 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SF3B3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SF3B3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where SF3B3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.740	0.909	.022	10	view →
PDAC	DFS	Median	III,IV	0.326	0.730	.008	5	view →
CCRCC	OS	Median	All	0.899	0.983	.016	4	view →
LSCC	OS	Median	II,III,IV	0.885	0.633	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SF3B3 tumor-vs-normal RNA expression · all SF3B3 data types