SF3B2

Across TCGA pan-cancer cohorts, SF3B2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SF3B2 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SF3B2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SF3B2 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

HNSC, COAD, and PDAC are the cancer types where SF3B2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.733	0.939	.002	29	view →
COAD	DFS	Median	All	1.000	0.893	.030	24	view →
PDAC	OS	Tertile	All	0.984	0.647	.011	17	view →
UCEC	OS	Median	All	0.983	0.865	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SF3B2–HNSC (OS)

Open the HNSC breakdown →