SF3B2

Across TCGA patient cohorts, SF3B2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3B2-associated genes across cancer lineages are MSH2, MSH6, and FASN. Each is linked with SF3B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B2-to-partner and partner-to-SF3B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by SF3B2-low versus SF3B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B2→partner) and Y-score (partner→SF3B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.332	-3.295	<.001	.009	3	2
UCEC	MSH6 →	-0.363	-1.906	.006	.016	3	2
UCEC	FASN →	+0.422	+3.459	.007	.005	3	1
UCEC	ACC1 →	+0.341	+1.750	.019	.049	3	1
UCEC	N-Ras →	-0.118	-2.565	.013	.010	3	1
UCEC	ARID1A →	-0.169	-3.159	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MSH2 by SF3B2 expression — UCEC

Explore this box plot interactively →