SF3B2

Across TCGA cell cohorts, SF3B2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,934 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SF3B2-associated GO terms across cancer lineages are Positive regulation of attachment of mitotic spindle microtubules to kinetochore, Regulation of metaphase plate congression, and Regulation of attachment of mitotic spindle microtubules to kinetochore. Each is linked with SF3B2 in more than 17 cancer types. Because this analysis shows association rather than direction, both SF3B2-to-partner and partner-to-SF3B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of attachment of mitotic spindle microtubules to kinetochore grouped by SF3B2-low versus SF3B2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B2→partner) and Y-score (partner→SF3B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.187	+0.694	<.001	<.001	3	18
URINARY_TRACT	Regulation of metaphase plate congression →	+0.180	+0.815	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.162	+1.049	.004	<.001	3	16
SOFT_TISSUE	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.140	+0.463	<.001	.001	3	15
BONE	Double-strand break repair via break-induced replication →	+0.236	+0.588	.005	.001	3	15
URINARY_TRACT	mRNA alternative polyadenylation →	+0.104	+1.048	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,934 associations by consensus.

Positive regulation of attachment of mitotic spindle microtubules to kinetochore by SF3B2 expression — URINARY_TRACT

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