SF3B2

Across TCGA cell cohorts, SF3B2 mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SF3B2-associated genes across cancer lineages are CTXN3, UGT2B11, and H4C13. Each is linked with SF3B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B2-to-partner and partner-to-SF3B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTXN3 grouped by SF3B2-low versus SF3B2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B2→partner) and Y-score (partner→SF3B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CTXN3 →	+0.311	+3.824	<.001	.002	3	1
LUNG_SCLC	UGT2B11 →	+0.468	+3.070	.002	.009	3	1
LUNG_SCLC	H4C13 →	+0.529	+3.762	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
LARGE_INTESTINE	CEP76 →	+0.659	+3.502	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

CTXN3 by SF3B2 expression — LUNG_SCLC

Explore this box plot interactively →