Across TCGA patient cohorts, SF3A3 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3A3-associated genes across cancer lineages are JNK2, MEK1, and MSH2. Each is linked with SF3A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3A3-to-partner and partner-to-SF3A3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3A3→partner) and Y-score (partner→SF3A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.181	+2.000	.020	.010	3	2
UCEC	MEK1 →	+0.505	+3.700	<.001	.001	3	1
UCEC	MSH2 →	-0.327	-1.973	<.001	.029	3	1
UCEC	PRDX1 →	+0.162	+2.000	.044	.030	3	1
UCEC	Rad50 →	-0.291	-3.169	.002	<.001	3	1
UCEC	STAT5a →	+0.314	+2.000	.045	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

SF3A3 survival (RNA) · tumor vs normal (RNA) · all SF3A3 data types