SF3A2

Across TCGA pan-cancer cohorts, SF3A2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SF3A2 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SF3A2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SF3A2 expression acts as an unfavorable survival marker.

LUAD, SCLC, and LUSC are the cancer types where SF3A2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.502	0.835	<.001	28	view →
SCLC	OS	Median	II,III,IV	0.082	0.702	<.001	27	view →
LUSC	OS	Median	II,III,IV	0.172	0.743	.003	24	view →
SKCM	DFS	Median	All	0.253	0.733	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SF3A2–LUAD (OS)

Open the LUAD breakdown →