SF3A2

Across TCGA patient cohorts, SF3A2 mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SF3A2-associated genes across cancer lineages are TVP23BP2, ZNF736P3Y, and RBAK-RBAKDN. Each is linked with SF3A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3A2-to-partner and partner-to-SF3A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TVP23BP2 grouped by SF3A2-low versus SF3A2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3A2→partner) and Y-score (partner→SF3A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TVP23BP2 →	+0.035	+3.292	.001	.006	3	1
LUAD	ZNF736P3Y →	+0.049	+7.930	<.001	.008	3	1
UCEC	RBAK-RBAKDN →	+0.121	+2.753	<.001	.009	3	1
UCEC	MIR6075 →	+0.339	+3.316	.004	.002	3	1
UCEC	TBC1D3L →	+0.571	+3.111	.003	.003	3	1
UCEC	PDCD6IPP1 →	+0.197	+3.028	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

TVP23BP2 by SF3A2 expression — SKCM

Explore this box plot interactively →