SF3A2

Across TCGA cell cohorts, SF3A2 mutation is significantly associated with the RNA expression of many other genes, with 534 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SF3A2-associated genes across cancer lineages are LY6G6F, PRAMEF19, and C9orf92. Each is linked with SF3A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3A2-to-partner and partner-to-SF3A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6G6F grouped by SF3A2-low versus SF3A2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3A2→partner) and Y-score (partner→SF3A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LY6G6F →	+0.036	+4.643	<.001	.008	3	1
BLOOD_Leukemia	PRAMEF19 →	+0.016	+4.969	.001	.003	3	1
BLOOD_Leukemia	C9orf92 →	+0.081	+4.539	<.001	.007	3	1
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1
STOMACH	OR6B1 →	+0.015	+4.285	<.001	.007	3	1
STOMACH	RD3L →	+0.047	+4.129	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 534 associations by consensus.

LY6G6F by SF3A2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →