SF3A1

Across TCGA pan-cancer cohorts, SF3A1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SF3A1 data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SF3A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SF3A1 expression acts as an unfavorable survival marker.

HNSC, LUSC, and ESCA are the cancer types where SF3A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.013	0.768	<.001	30	view →
LUSC	OS	Median	III,IV	0.001	0.684	<.001	24	view →
ESCA	OS	Median	All	0.128	0.704	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SF3A1–HNSC (OS)

Open the HNSC breakdown →