SF3A1

Across TCGA pan-cancer cohorts, SF3A1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SF3A1 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SF3A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SF3A1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where SF3A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.809	0.943	.004	41	view →
COAD	DFS	Median	All	1.000	0.886	.020	36	view →
LUAD	OS	Quartile	All	0.943	0.716	.012	25	view →
LSCC	OS	Quartile	II,III,IV	0.948	0.636	.013	21	view →
GBM	OS	Median	All	0.474	0.287	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SF3A1–HNSC (OS)

Open the HNSC breakdown →