SF3A1

Across TCGA patient cohorts, SF3A1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3A1-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and Cyclin-B1. Each is linked with SF3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3A1-to-partner and partner-to-SF3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SF3A1-low versus SF3A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3A1→partner) and Y-score (partner→SF3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.212	-3.321	.003	.010	3	2
UCEC	Notch1 →	+0.154	+2.179	.012	.034	3	2
UCEC	Cyclin-B1 →	+0.689	+2.807	.004	.003	3	2
UCEC	EGFR_pY1068 →	-0.300	-2.115	.006	.019	3	1
UCEC	eIF4E →	+0.184	+3.013	.046	.018	3	1
UCEC	A-Raf_pS299 →	-0.168	-2.459	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

JNK_pT183_Y185 by SF3A1 expression — UCEC

Explore this box plot interactively →