SF3A1

Across TCGA cell cohorts, SF3A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,778 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SF3A1-associated GO terms across cancer lineages are DNA-templated transcription initiation, U2-type prespliceosome assembly, and Positive regulation of mitotic cytokinesis. Each is linked with SF3A1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SF3A1-to-partner and partner-to-SF3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by SF3A1-low versus SF3A1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3A1→partner) and Y-score (partner→SF3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.094	+1.374	<.001	<.001	3	16
BONE	U2-type prespliceosome assembly →	+0.129	+1.003	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cytokinesis →	+0.170	+0.943	<.001	<.001	3	16
PANCREAS	Negative regulation of DNA-templated transcription initiation →	+0.109	+0.796	<.001	<.001	3	16
PANCREAS	Negative regulation of transcription initiation by RNA polymerase II →	+0.109	+0.796	<.001	<.001	3	16
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.210	+0.996	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,778 associations by consensus.

DNA-templated transcription initiation by SF3A1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →