SF3A1

Across TCGA cell cohorts, SF3A1 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SF3A1-associated genes across cancer lineages are F9, PTH2, and DPPA2. Each is linked with SF3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3A1-to-partner and partner-to-SF3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by SF3A1-low versus SF3A1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3A1→partner) and Y-score (partner→SF3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	F9 →	+0.035	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	PTH2 →	+0.058	+5.169	.002	.001	3	1
BLOOD_Lymphoma	DPPA2 →	+0.339	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	CSN3 →	+0.186	+4.350	<.001	.005	3	1
LARGE_INTESTINE	UBXN8 →	+0.859	+3.212	.001	.006	3	1
LARGE_INTESTINE	LY86 →	+0.049	+2.772	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

F9 by SF3A1 expression — BLOOD_Lymphoma

Explore this box plot interactively →