SEZ6L2

Across TCGA patient cohorts, SEZ6L2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,757 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEZ6L2-associated genes across cancer lineages are ASPHD1, RTN2, and CDIPTOSP. Each is linked with SEZ6L2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SEZ6L2-to-partner and partner-to-SEZ6L2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEZ6L2 versus ASPHD1 in CCRCC, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L2→partner) and Y-score (partner→SEZ6L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ASPHD1 →	+1.661	+0.704	<.001	<.001	3	7
BRCA	RTN2 →	+0.640	+0.326	<.001	.001	3	5
LSCC	CDIPTOSP →	+0.870	+0.580	<.001	<.001	3	4
BRCA	RUNDC3A-AS1 →	+0.593	+0.453	<.001	.002	3	4
GBM	APLP1 →	+0.893	+0.377	<.001	<.001	3	4
OV	EPHA10 →	+0.738	+0.408	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,757 associations by consensus.

SEZ6L2 vs ASPHD1 — CCRCC

Explore this scatter interactively →