SEZ6L2

Across TCGA patient cohorts, SEZ6L2 mutation is significantly associated with the RNA expression of many other genes, with 5,469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEZ6L2-associated genes across cancer lineages are RNU6-176P, DYNLT3P2, and RN7SL369P. Each is linked with SEZ6L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEZ6L2-to-partner and partner-to-SEZ6L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-176P grouped by SEZ6L2-low versus SEZ6L2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L2→partner) and Y-score (partner→SEZ6L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-176P →	+0.280	+3.080	<.001	.002	3	3
COAD	DYNLT3P2 →	+0.416	+2.920	<.001	.004	3	3
LIHC	RN7SL369P →	+0.098	+3.704	.001	.005	3	3
UCEC	RHBDD3 →	+0.334	+2.736	.001	<.001	3	3
UCEC	ERCC2 →	+0.292	+1.584	.005	.009	3	3
UCEC	SGTA →	+0.444	+2.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,469 associations by consensus.

RNU6-176P by SEZ6L2 expression — COAD

Explore this box plot interactively →