SEZ6L2

Across TCGA patient cohorts, SEZ6L2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEZ6L2-associated genes across cancer lineages are PDCD4, Cyclin-B1, and c-Jun_pS73. Each is linked with SEZ6L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEZ6L2-to-partner and partner-to-SEZ6L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SEZ6L2-low versus SEZ6L2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L2→partner) and Y-score (partner→SEZ6L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDCD4 →	-0.414	-2.321	.006	.032	3	3
COAD	Cyclin-B1 →	+0.577	+2.824	.031	.034	3	3
UCEC	c-Jun_pS73 →	-0.109	-1.986	.017	.008	3	3
SKCM	CD49b →	+0.288	+1.339	.001	.044	3	2
SKCM	Dvl3 →	-0.209	-2.321	.008	.033	3	2
COAD	Caspase-7-cleavedD198 →	+1.313	+3.000	<.001	.035	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

PDCD4 by SEZ6L2 expression — SKCM

Explore this box plot interactively →