SEZ6L2

Across TCGA cell cohorts, SEZ6L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,329 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SEZ6L2-associated GO terms across cancer lineages are Autophagy, Process utilizing autophagic mechanism, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with SEZ6L2 in more than 15 cancer types. Because this analysis shows association rather than direction, both SEZ6L2-to-partner and partner-to-SEZ6L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Autophagy grouped by SEZ6L2-low versus SEZ6L2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L2→partner) and Y-score (partner→SEZ6L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.048	+1.406	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.048	+1.406	<.001	.001	3	16
KIDNEY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.123	+2.963	<.001	<.001	3	14
STOMACH	Regulation of myoblast fusion →	+0.097	+2.120	.005	.004	3	14
STOMACH	Negative regulation of myoblast fusion →	+0.106	+2.097	.004	.005	3	14
STOMACH	Regulation of proteasomal protein catabolic process →	+0.063	+2.070	.004	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,329 associations by consensus.

Autophagy by SEZ6L2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →