SEZ6L2

Across TCGA cell cohorts, SEZ6L2 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEZ6L2-associated genes across cancer lineages are ACER1, LYZL4, and CT45A9. Each is linked with SEZ6L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEZ6L2-to-partner and partner-to-SEZ6L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by SEZ6L2-low versus SEZ6L2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L2→partner) and Y-score (partner→SEZ6L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACER1 →	+0.185	+3.672	.006	.003	3	2
KIDNEY	LYZL4 →	+0.050	+5.000	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	CT45A9 →	+0.165	+4.736	<.001	.009	3	1
BLOOD_Lymphoma	CFHR5 →	+0.009	+2.807	<.001	.004	3	1
BLOOD_Lymphoma	OR2T35 →	+0.045	+2.616	.003	.008	3	1
BLOOD_Lymphoma	DPRX →	+0.021	+2.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ACER1 by SEZ6L2 expression — BLOOD_Leukemia

Explore this box plot interactively →