SEZ6

Across TCGA patient cohorts, SEZ6 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,598 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SEZ6-associated proteins across cancer lineages are PARP1, SUGP2, and TRPM4. Each is linked with SEZ6 in more than 3 cancer types. Because this analysis shows association rather than direction, both SEZ6-to-partner and partner-to-SEZ6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEZ6 versus PARP1 in HNSC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6→partner) and Y-score (partner→SEZ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PARP1 →	+0.537	+0.578	<.001	.001	3	4
HNSC	SUGP2 →	+0.303	+0.403	<.001	<.001	3	4
PDAC	TRPM4 →	-0.472	-0.317	<.001	.003	3	4
HNSC	DDAH2 →	+0.463	+0.468	<.001	.001	3	4
LSCC	DEK →	+0.347	+0.417	.004	<.001	3	4
PDAC	NCOR2_S1902 →	+0.826	+0.286	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,598 associations by consensus.

SEZ6 vs PARP1 — HNSC

Explore this scatter interactively →