SEZ6

Across TCGA patient cohorts, SEZ6 protein abundance is significantly associated with the RNA expression of many other genes, with 2,776 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEZ6-associated genes across cancer lineages are RNA5SP379, RNU6-196P, and RPL26P26. Each is linked with SEZ6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEZ6-to-partner and partner-to-SEZ6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEZ6 versus RNA5SP379 in OV, with a Pearson correlation of 0.96.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6→partner) and Y-score (partner→SEZ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNA5SP379 →	+2.275	+2.661	<.001	<.001	3	1
OV	RNU6-196P →	+1.230	+2.661	.001	<.001	3	1
OV	RPL26P26 →	+0.415	+2.661	.001	<.001	3	1
OV	MIR4319 →	+1.435	+2.603	<.001	<.001	2	2
GBM	SOS2 →	+0.361	+0.580	.001	.001	3	1
GBM	RIN3 →	-0.555	-0.574	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,776 associations by consensus.

SEZ6 vs RNA5SP379 — OV

Explore this scatter interactively →