SEZ6

Across TCGA patient cohorts, SEZ6 mutation is significantly associated with the RNA expression of many other genes, with 3,375 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEZ6-associated genes across cancer lineages are MIER3, OR10AE1P, and ZNHIT3. Each is linked with SEZ6 in more than 3 cancer types. Because this analysis shows association rather than direction, both SEZ6-to-partner and partner-to-SEZ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIER3 grouped by SEZ6-low versus SEZ6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6→partner) and Y-score (partner→SEZ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIER3 →	+0.462	+2.447	.002	.001	3	4
BRCA	OR10AE1P →	+0.026	+5.548	<.001	.001	3	3
UCEC	ZNHIT3 →	+0.402	+2.021	<.001	<.001	3	3
UCEC	TAF9 →	+0.689	+2.700	<.001	<.001	3	3
UCEC	FAM151B →	+0.283	+2.159	<.001	.002	3	3
UCEC	SAR1B →	+0.585	+2.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,375 associations by consensus.

MIER3 by SEZ6 expression — UCEC

Explore this box plot interactively →