SEZ6

Across TCGA patient cohorts, SEZ6 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEZ6-associated genes across cancer lineages are p90 RSK, IGFBP2, and ATM. Each is linked with SEZ6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEZ6-to-partner and partner-to-SEZ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by SEZ6-low versus SEZ6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6→partner) and Y-score (partner→SEZ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p90 RSK →	+0.252	+3.000	.009	.034	3	2
UCEC	IGFBP2 →	-0.476	-1.874	.034	.049	3	2
UCEC	ATM →	-0.459	-2.807	.003	.003	3	2
UCEC	eIF4E →	+0.154	+1.736	.035	.007	3	1
UCEC	JNK2 →	+0.230	+3.611	<.001	.001	3	1
UCEC	MEK1 →	+0.371	+2.087	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p90 RSK by SEZ6 expression — SKCM

Explore this box plot interactively →