SEZ6

Across TCGA cell cohorts, SEZ6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,988 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SEZ6-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Regulation of myoblast fusion, and Negative regulation of myoblast fusion. Each is linked with SEZ6 in more than 9 cancer types. Because this analysis shows association rather than direction, both SEZ6-to-partner and partner-to-SEZ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by SEZ6-low versus SEZ6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6→partner) and Y-score (partner→SEZ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.060	+1.709	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.101	+0.122	.001	.001	3	8
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.107	+2.863	.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.074	+0.115	.001	.003	3	8
OVARY	Regulation of nucleotide-excision repair →	+0.111	+0.138	<.001	.001	1	10
SOFT_TISSUE	Regulation of RNA splicing →	+0.079	+1.572	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,988 associations by consensus.

Epigenetic regulation of gene expression by SEZ6 expression — SOFT_TISSUE

Explore this box plot interactively →