SETX

Across TCGA patient cohorts, SETX protein abundance is significantly associated with the RNA expression of many other genes, with 14,868 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SETX-associated genes across cancer lineages are GLE1, DDX31, and EXOSC2. Each is linked with SETX in more than 5 cancer types. Because this analysis shows association rather than direction, both SETX-to-partner and partner-to-SETX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SETX versus GLE1 in HNSC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETX→partner) and Y-score (partner→SETX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GLE1 →	+0.693	+0.180	<.001	<.001	3	6
HNSC	DDX31 →	+0.898	+0.329	<.001	<.001	3	6
HNSC	EXOSC2 →	+0.799	+0.227	<.001	<.001	3	6
HNSC	REXO4 →	+0.776	+0.222	.001	<.001	3	6
HNSC	SET →	+0.596	+0.177	.001	<.001	3	5
OV	TTF1 →	+0.547	+0.268	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,868 associations by consensus.

SETX vs GLE1 — HNSC

Explore this scatter interactively →