SETX

Across TCGA patient cohorts, SETX mutation is significantly associated with the RNA expression of many other genes, with 6,346 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETX-associated genes across cancer lineages are UBE2M, CXCL9, and CD8A. Each is linked with SETX in more than 3 cancer types. Because this analysis shows association rather than direction, both SETX-to-partner and partner-to-SETX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2M grouped by SETX-low versus SETX-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETX→partner) and Y-score (partner→SETX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UBE2M →	+0.309	+2.662	.003	<.001	3	4
UCEC	CXCL9 →	+2.087	+2.432	<.001	<.001	3	4
COAD	CD8A →	+1.048	+2.807	<.001	.002	3	4
COAD	LRRC36 →	-0.789	-2.169	<.001	.003	3	4
UCEC	NCAPH2 →	+0.569	+2.432	<.001	<.001	3	4
UCEC	MTHFD2 →	+0.522	+1.243	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,346 associations by consensus.

UBE2M by SETX expression — COAD

Explore this box plot interactively →