SETX

Across TCGA cell cohorts, SETX RNA expression is significantly associated with the go_rna of many other GO terms, with 4,600 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SETX-associated GO terms across cancer lineages are Positive regulation of termination of RNA polymerase II transcription, Positive regulation of termination of DNA-templated transcription, and Termination of RNA polymerase II transcription. Each is linked with SETX in more than 18 cancer types. Because this analysis shows association rather than direction, both SETX-to-partner and partner-to-SETX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of termination of RNA polymerase II transcription grouped by SETX-low versus SETX-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETX→partner) and Y-score (partner→SETX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of termination of RNA polymerase II transcription →	+0.155	+0.801	<.001	<.001	3	19
OESOPHAGUS	Positive regulation of termination of DNA-templated transcription →	+0.155	+0.801	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Termination of RNA polymerase II transcription →	+0.144	+0.720	<.001	.004	3	19
BONE	Establishment of RNA localization →	+0.093	+0.606	<.001	<.001	3	19
SOFT_TISSUE	Regulation of mRNA splicing, via spliceosome →	+0.086	+0.921	.001	<.001	3	17
BONE	RNA localization →	+0.085	+0.466	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,600 associations by consensus.

Positive regulation of termination of RNA polymerase II transcription by SETX expression — OESOPHAGUS

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