SETX

Across TCGA cell cohorts, SETX mutation is significantly associated with the RNA expression of many other genes, with 1,423 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETX-associated genes across cancer lineages are ARMC1, HTR1A, and CSMD1. Each is linked with SETX in more than 2 cancer types. Because this analysis shows association rather than direction, both SETX-to-partner and partner-to-SETX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARMC1 grouped by SETX-low versus SETX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETX→partner) and Y-score (partner→SETX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARMC1 →	+0.362	+3.067	.003	.009	3	3
URINARY_TRACT	HTR1A →	+0.022	+4.087	<.001	.009	3	2
PANCREAS	CSMD1 →	+0.746	+4.011	.002	.009	3	2
CNS	OR8B4 →	+0.022	+3.772	<.001	.008	3	2
BLOOD_Lymphoma	PAQR9 →	+0.116	+3.618	.006	.003	3	2
BLOOD_Leukemia	PYROXD1 →	+0.634	+3.215	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,423 associations by consensus.

ARMC1 by SETX expression — LARGE_INTESTINE

Explore this box plot interactively →