SETSIP

Across TCGA pan-cancer cohorts, SETSIP RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SETSIP data layer compared with 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SETSIP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SETSIP expression acts as an unfavorable survival marker, although some lineages such as KIRC and CESC show a favorable association.

LIHC, KIRC, and CESC are the cancer types where SETSIP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.526	0.769	<.001	53	view →
KIRC	DFS	Tertile	II,III,IV	0.822	0.524	.001	42	view →
CESC	OS	Quartile	II,III,IV	0.872	0.508	<.001	42	view →
KIRP	OS	Quartile	All	0.477	0.865	<.001	40	view →
SKCM	DFS	Median	II,III,IV	0.466	0.665	<.001	34	view →
PAAD	OS	Median	All	0.278	0.524	.002	32	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
ACC	DFS	Median	All	0.433	0.716	.003	26	view →
LUSC	OS	Quartile	All	0.499	0.320	.006	25	view →
READ	DFS	Tertile	All	0.831	0.235	<.001	25	view →
COAD	OS	Quartile	IV	0.077	0.616	.014	12	view →
SARC	OS	Median	All	0.681	0.797	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SETSIP–LIHC (OS)

Open the LIHC breakdown →