Across TCGA pan-cancer cohorts, SETP8 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SETP8’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SETP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SETP8 is over-expressed in tumor.
HNSC, UCEC, and COAD are the cancer types where SETP8 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETP8 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.