SETP6

Across TCGA pan-cancer cohorts, SETP6 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated SETP6 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SETP6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SETP6 expression acts as an unfavorable survival marker, although some lineages such as LAML and GBM show a favorable association.

KIRC, UVM, and LUSC are the cancer types where SETP6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.746	0.834	.001	51	view →
UVM	OS	Tertile	III,IV	0.225	0.721	<.001	36	view →
LUSC	DFS	Tertile	All	0.646	0.826	.003	30	view →
STAD	OS	Quartile	II,III,IV	0.397	0.647	.008	24	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
ESCA	DFS	Median	All	0.395	0.599	.002	15	view →
UCS	DFS	Median	II,III,IV	0.263	0.544	.012	14	view →
LAML	DFS	Tertile	All	0.550	0.269	.004	12	view →
PAAD	DFS	Tertile	All	0.319	0.503	.021	12	view →
MESO	OS	Tertile	II,III,IV	0.234	0.601	.035	9	view →
GBM	OS	Median	All	0.499	0.340	.011	7	view →
DLBC	DFS	Tertile	IV	0.120	0.784	.045	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SETP6–KIRC (DFS)

Open the KIRC breakdown →