Across TCGA pan-cancer cohorts, SETP20 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SETP20’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where SETP20 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SETP20 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.
COAD, LUSC, and HNSC are the cancer types where SETP20 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETP20 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.