SETP1

Across TCGA pan-cancer cohorts, SETP1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SETP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SETP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SETP1 is over-expressed in tumor.

KIRC, BRCA, and HNSC are the cancer types where SETP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.408	<.001	12	view →
BRCA	All	III,IV	+0.107	<.001	6	view →
HNSC	Male	All	+0.075	<.001	6	view →
LIHC	All	All	+0.042	<.001	6	view →
COAD	All	II,III,IV	+0.044	.005	5	view →
THCA	All	All	+0.033	.003	5	view →
LUAD	All	All	+0.050	<.001	3	view →
ESCA	All	II,III,IV	+0.185	.033	2	view →
BLCA	All	All	+0.065	.035	2	view →
PRAD	All	All	+0.022	.021	2	view →
READ	Female	All	+0.100	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SETP1–KIRC

Open the KIRC breakdown →